Induction of drug-metabolizing enzymes by fractionated commercial polybrominated biphenyls (PBBs)
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منابع مشابه
Induction of drug-metabolizing enzymes by fractionated commercial polybrominated biphenyls (PBBs).
Induction of Drug-Metabolizing Enzymes by Fractionated Commercial Polybrominated Biphenyls (PBBs). ROBERTSON, L., PARKINSON, A., AND SAFE, S. (1981). Toxicol. Appl. Pharmacol. 57, 254-262. A commercial polybrominated biphenyl mixture was separated chromatographically into two fractions on neutral alumina (AA and A,) and into three fractions on Florisil (FA, Fa, and Fc) by sequential elution wit...
متن کاملToxicity of polybrominated biphenyls (PBBs) in Domestic and laboratory animals.
The composition, environmental fate, and effects of the polybrominated biphenyls (Firemaster BP-6 or FF-1) involved in the accidental contamination of cattle feed in Michigan in 1973 are reviewed. Toxic effects referred to in this report are limited to those occurring in domestic and laboratory animals and include general toxicity, neurobehavioral toxicity, immunotoxicity, reproductive toxicity...
متن کاملAbsence of plant uptake and translocation of polybrominated biphenyls (PBBs).
Studies of polybrominated biphenyl (PBB) uptake by plants have been conducted in hydroponic solutions and in greenhouse experiments with soil. Autoradiograms of corn and soybean seedlings grown in hydroponic solutions showed no translocation of 14C-PBB from 14C-PBB-treated solutions to plant tops or within the leaf from 14C-PBB-treated spots on the upper leaf surface. A significant portion of t...
متن کاملInduction of drug metabolizing enzymes in polybrominated biphenyl-fed lactating rats and their pups.
Polybrominated biphenyls (PBBs) cause a mixed-type (phenobarbital- plus 3-methylcholanthrene-like) induction of liver microsomal drug metabolizing enzymes in rats. However, 2,2',4,4',5,5'-hexabromobiphenyl and 2,2',3,4,4',5,5'-heptabromobiphenyl, which together comprise less than 80% of PBBs (FireMaster), were shown to be strictly phenobarbital-type inducers. Other components (unidentified) mus...
متن کامل[Involvement of microRNA in the induction of drug-metabolizing enzymes].
MicroRNAs (miRNAs) are small noncoding RNAs of about 20 nucleotides in length and participate in the post-transcriptional regulation of gene expression. Accumulating evidence indicates that miRNA binds to 3'-UTR of its target mRNAs and thereby destabilizes the transcripts or suppresses the translation. It is expected that miRNAs could have diverse functions and therefore play a role in the gene...
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ژورنال
عنوان ژورنال: Toxicology and Applied Pharmacology
سال: 1981
ISSN: 0041-008X
DOI: 10.1016/0041-008x(81)90287-8